Dissolving Microneedles as Skin Allergy Test Device
نویسندگان
چکیده
منابع مشابه
Chitin microneedles for an easy-to-use tuberculosis skin test.
An easy-to-use tuberculosis skin test is developed with chitin microneedles that deliver purified protein derivative at the correct skin depth and result in a positive test in BCG-immunized guinea pigs.
متن کاملMinimally invasive protein delivery with rapidly dissolving polymer microneedles.
Biomolecules, including proteins, peptides, and vaccines, make up a large and potent portion of all new drugs and hold great promise for the future of therapeutics. Although oral delivery of these biotherapeutics would be desirable, there is low bioavailability of biomolecules administered by this route due to enzymatic degradation and poor absorption in the GI tract, as well as first-pass meta...
متن کاملSkin Prick Test Reactivity to Common Aero and Food Allergens among Children with Allergy
Background: The prevalence of allergic diseases has risen in the last decades. The objective of this study was to determine the common allergens in children via the skin prick test.Methods: This cross-sectional study recruited 313 allergic children (4 months to 18 years old) referred to the Asthma and Allergy Clinic of Children’s Medical Center in Tehran. A questionnaire containing demographic ...
متن کاملPrecise microinjection into skin using hollow microneedles.
Hollow needles of micron dimensions have previously been fabricated and envisioned for use with transdermal patches or infusion pumps to achieve painless delivery of drugs to the skin for local and systemic effects without the need for hypodermic needles. However, little work has been carried out to identify methods to effectively use hollow microneedles for drug delivery. To address this need,...
متن کاملTherapeutic Drug Monitoring of Vancomycin in Dermal Interstitial Fluid Using Dissolving Microneedles
OBJECTIVE To design an alternative painless method for vancomycin (VCM) monitoring by withdrawing interstitial fluid (ISF) the skin using dissolving microneedles (DMNs) and possibly replace the conventional clinical blood sampling method. METHODS Male Wistar rats were anesthetized with 50 mg/kg sodium pentobarbital. Vancomycin at 5 mg/mL in saline was intravenously administered via the jugula...
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ژورنال
عنوان ژورنال: Biological and Pharmaceutical Bulletin
سال: 2017
ISSN: 0918-6158,1347-5215
DOI: 10.1248/bpb.b16-00768